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HEPATOPROTECTIVE EFFECT OF CAMEL URINE AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RATS

How to cite

Salawa M. E. Khougli El Hassan ,A. M, Mohamed ,O. Y and Majid, A. A. ,2009, HEPATOPROTECTIVE EFFECT OF CAMEL URINE AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN RATS,Journal of Science and Technology,10 (2) ,pp:130-137

Authors:
By Salawa M. E. Khougli El Hassan ,A. M, Mohamed ,O. Y and Majid, A. A. ,
Year:
2009
Keywords
Hepatotxeiaty, camel, urine, hepatoprotative effect.
Abstract
Oral administration to rats of 4ml/100g body weight (B.W.) of 24 hour adult she-camel urine (24 HCU) and 2ml/100g BW of young she-camel early morning urine (EMU); one hour before carbon tetrachloride (CCl4) injection resulted in reduced mortality to 0 and 40% respectively. 8 ml of the (24HCU) were lethal to rats in less than 55 minutes following oral administration. Different doses of the above camel urine and the latter chloroformic extract were assessed for their effect on rat liver transaminases activities. Reduction of the high activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) induced by CCL4 and the amelioration of the liver hepatotoxicity were noticed after the administration of 4ml, 2ml and 0.2ml respectively. A linear decrease of ALT activity with double dosing female camel urine chloroformic extract (CE) was observed and addition of these components one hour after CCL4 administration gave the same results. These results indicated that, camel urine, as crude or chloroformic extract played an important role as an antioxidant and efficiently acted as a protective agent against liver damage.
الملخص
في مذه الدراسه تم إستخدام بول النوق البكره الصباحي و المجمع خلال 42 ساعه قبل و بعد ساعه من حقنه رابع كلوريد الكربون بجرعات 4.2 مل/ 100 جم من وزن الجرز بالتالي أدت هذه ALT الجرعات إلى حماية الكبد من تأثير رابع كلوريد الكربون بالإنخفاض الملاحظ في إنزيمي
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